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N-piperidine Ibrutinib
Price range: 142 CAD through 1,888 CAD
Products Details
Product Description
– N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
Web ID
– T9408
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H22N6O
References
– Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.
CAS Number
– 330785-90-5
Molecular Weight
– C22H22N6O
Compound Purity
– 0.9665
SMILES
– NC1=C2C(=NN(C2=NC=N1)C3CCNCC3)C4=CC=C(OC5=CC=CC=C5)C=C4
Pathway
– Angiogenesis|||Tyrosine Kinase/Adaptors
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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