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BSJ-4-116
Price range: 80 CAD through 1,525 CAD
Products Details
Product Description
– BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
Web ID
– T9117
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C40H49ClN8O8S
Citations
– 1. Liu S, Wu J, Lu X, et al.Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.Experimental Cell Research.2023: 113613.
References
– Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021;17(6):675-683.
CAS Number
– 2519823-34-6
Molecular Weight
– C40H49ClN8O8S
Compound Purity
– 0.9909
SMILES
– O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCN4C[C@H](NC=5N=C(NC6=C(S(C(C)C)(=O)=O)C=CC=C6)C(Cl)=CN5)CCC4)=O
Pathway
– Cell Cycle/Checkpoint|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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