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Products Details
Product Description
– PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM and degrades SMARCA4 in MV411 with a DC50 ranging from 100 to 500 nM.
Web ID
– T88983
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C56H65N11O5S
CAS Number
– 2568277-84-7
Molecular Weight
– C56H65N11O5S
SMILES
– NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5=CC=C(C[C@@H]6CC[C@@H](C(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)CC6)C=C5)C=C(N=N1)C%10=C(O)C=CC=C%10
Product type
– PROTAC
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