BMS-681
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BMS-681

SKU T69523-25 mg Category Brand:

Price range: 5,552 CAD through 10,240 CAD

Products Details

Product Description

– BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the orthosteric pocket and CCR2-RA-[R] in the intracellular allosteric G-protein binding site. When chemokine binding is inhibited, modulation responses implicated in several inflammatory and neurodegenerative diseases, including atherosclerosis, multiple sclerosis, asthma, neuropathic pain, diabetic nephropathy, and cancer can be controlled. This action occurs as the migration of monocytes, immature dendritic cells, and T-cell subpopulations towards endogenous CC chemokine ligands is mediated.

Web ID

– T69523

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H36F3N5O

CAS Number

– 2760844-13-9

Molecular Weight

– C26H36F3N5O

SMILES

– N(C=1C2=C(C=CC(C(F)(F)F)=C2)N=CN1)[C@@H]3C(=O)N(CC3)[C@H]4[C@@H](CCC)C[C@@H](N(C(C)C)C)CC4

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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