Vadimezan
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Vadimezan

SKU T6273-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 74 CAD through 1,053 CAD

Products Details

Product Description

– Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

Web ID

– T6273

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H14O4

Citations

– 1. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease. Cell Death & Differentiation. 2021: 1-19. 2. Chen C, Zhang Y, Tao M, et al. Atrial Natriuretic Peptide Attenuates Colitis via Inhibition of the cGAS-STING Pathway in Colonic Epithelial Cells. International Journal of Biological Sciences. 2022, 18(4): 1737-1754. 3. Xu X, Huang Z, Huang Z, et al.Butyrate attenuates intestinal inflammation in Crohn’s disease by suppressing pyroptosis of intestinal epithelial cells via the cGSA-STING-NLRP3 axis.International Immunopharmacology.2024, 143: 113305. 4. Chen Y, Zhi Y, Zhong H, et al.Inhibition of Kv1. 3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation.Pharmacological Research.2025: 107623.

References

– Cai Y, et al. Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma. Int J Biol Sci. 2023 Aug 28;19(14):4627-4643.

CAS Number

– 117570-53-3

Molecular Weight

– C17H14O4

Compound Purity

– 0.9961

SMILES

– Cc1ccc2c(oc3c(CC(O)=O)cccc3c2=O)c1C

Pathway

– Microbiology/Virology|||Immunology/Inflammation|||Angiogenesis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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