U-73122
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U-73122

SKU T6243-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 720 CAD

Products Details

Product Description

– U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.

Web ID

– T6243

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H40N2O3

Citations

– 1. Wang X, Cai J, Lin B, et al. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity. 2021, 54(6): 1123-1136. e8. 2. Sudi S, Chin Y Z, Wasli N S, et al. Carpaine Promotes Proliferation and Repair of H9c2 Cardiomyocytes after Oxidative Insults. Pharmaceuticals. 2022, 15(2): 230. 3. Ma L, Gong F, Xu J, et al. Uncarboxylated osteocalcin reverses the high glucose‑induced inhibition of the osteogenic differentiation of MC3T3E1 cells via the GPRC6A/cAMP/PKA/AMPK signaling pathway. International Journal of Molecular Medicine. 2021 May;47(5):91. doi: 10.3892/ijmm.2021.4924. Epub 2021 Mar 31. 4. Zhu H, Liu X, Wang X, et al.Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways.European Journal of Pharmacology.2023: 176038. 5. Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12. 6. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11. 7. Zhong T, Chen S, Deng K, et al.Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal.International Immunopharmacology.2024, 132: 111870. 8. Gu Y P, Wang J M, Tian S, et al.Activation of TAS2R4 signaling attenuates podocyte injury induced by high glucose.Biochemical Pharmacology.2024: 116392. 9. Lin B, Zhou Y, Huang Z, et al.GPR34 senses demyelination to promote neuroinflammation and pathologies.Cellular & Molecular Immunology.2024: 1-14. 10. Yan J, Zhang C, Xu Y, et al.GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity.Nature immunology.2024: 1-11.

References

– Bleasdale JE, et al. J Pharmacol Exp Ther, 1990, 255(2), 756-768.

CAS Number

– 112648-68-7

Molecular Weight

– C29H40N2O3

Compound Purity

– 0.9798

SMILES

– COc1ccc2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCc2c1)NCCCCCCN1C(=O)C=CC1=O

Pathway

– Apoptosis|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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