UMI-77
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UMI-77

SKU T6034-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 1,840 CAD

Products Details

Product Description

– UMI-77 is a selective Mcl-1 inhibitor. UMI-77 binds to the BH3-binding groove of Mcl-1 with a Ki of 490 nM and is selective over other members of the Bcl-2 family.

Web ID

– T6034

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H14BrNO5S2

Citations

– 1. Cen X, Chen Y, Xu X, et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model. Nature Communications. 2020, 11(1): 1-13. 2. Xu Y, Chen Q, Jiang Y, et al.UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip.Journal of Proteome Research.2023

References

– Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575.

CAS Number

– 518303-20-3

Molecular Weight

– C18H14BrNO5S2

Compound Purity

– 0.9888

SMILES

– OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O

Pathway

– Apoptosis

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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