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SRT 1720
Price range: 50 CAD through 691 CAD
Products Details
Product Description
– SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and exhibits more than 230-fold lower potency for SIRT2 and SIRT3.
Web ID
– T5096
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H23N7OS
Citations
– 1. Wu Q, Hu Y, Jiang M, et al. Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells. International journal of molecular sciences. 2019, 20(17): 4132.
2. Lian L, Le Z, Wang Z, et al.SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation.Investigative Ophthalmology & Visual Science.2023, 64(3): 16-16.
3. Li L, Fu S, Wang J, et al.SRT1720 inhibits bladder cancer cell progression by impairing autophagic flux.Biochemical Pharmacology.2024: 116111.
4. Datta C, Das P, Dutta S, et al.AMPK activation reduces cancer cell aggressiveness via inhibition of monoamine oxidase A (MAO-A) expression/activity.Life Sciences.2024: 122857.
References
– Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6
CAS Number
– 925434-55-5
Molecular Weight
– C25H23N7OS
Compound Purity
– 0.997
SMILES
– O=C(NC1=C(C=CC=C1)C1=CN2C(CN3CCNCC3)=CSC2=N1)C1=CN=C2C=CC=CC2=N1
Pathway
– Autophagy|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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