A-674563 HCl (552325-73-2(free base))
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A-674563 HCl (552325-73-2(free base))

SKU T4444-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 123 CAD through 224 CAD

Products Details

Product Description

– A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].

Web ID

– T4444

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H23ClN4O

References

– Luo Y, Shoemaker A R, Liu X, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.[J]. Molecular Cancer Therapeutics, 2005, 4(6):977.

CAS Number

– 2070009-66-2

Molecular Weight

– C22H23ClN4O

Compound Purity

– 0.9969

SMILES

– CC=1C=2C(=CC=C(C2)C=3C=C(OC[C@H](CC4=CC=CC=C4)N)C=NC3)NN1.Cl

Pathway

– Chromatin/Epigenetic|||Cytoskeletal Signaling|||Cell Cycle/Checkpoint|||MAPK|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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