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Ziritaxestat
Price range: 69 CAD through 878 CAD
Products Details
Product Description
– Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
Web ID
– T4041
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C30H33FN8O2S
Citations
– 1. Yang Y, Zhang X, Zhang X, et al. Modulators of histone demethylase JMJD1C selectively target leukemic stem cells. FEBS Open Bio. 2020
2. Chen J, Guan Z, Dong N, et al. A novel LC‐MS/MS method for the determination of ziritaxestat in rat plasma and its pharmacokinetic study. Biomedical Chromatography. 2020: e4863.
3. Hu Y, Li L, Tian Y, et al.Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis.European Journal of Medicinal Chemistry.2023: 116029.
References
– Desroy N., et al. Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinicalal Evaluation for the Treatment of Idiopathic PulmoN/Ary Fibrosis. J Med Chem. 2017 May 11;60(9):3580-3590.
CAS Number
– 1628260-79-6
Molecular Weight
– C30H33FN8O2S
Compound Purity
– 0.9985
SMILES
– CCc1nc2c(C)cc(cn2c1CNc1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1
Pathway
– Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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