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Products Details
Product Description
– PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
Web ID
– T40334
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C47H63N11O6
References
– Degorce SL, et al. Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase. J Med Chem. 2020 Sep 24;63(18):10460-10473.
CAS Number
– 2712600-00-3
Molecular Weight
– C47H63N11O6
SMILES
– CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](CC3)N3CCN(CC3)C(=O)CCC(=O)N3CCC(CCN4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c12 |wU:15.18,12.11,(-.91,-3.09,;-1.94,-1.94,;-3.45,-2.26,;-1.46,-.48,;-2.37,.77,;-1.46,2.02,;,1.54,;1.33,2.31,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;5.33,-4.62,;4,-5.39,;2.67,-4.62,;6.67,-5.39,;6.67,-6.93,;8,-7.7,;9.34,-6.93,;9.34,-5.39,;8,-4.62,;10.67,-7.7,;10.67,-9.24,;12,-6.93,;13.34,-7.7,;14.67,-6.93,;14.67,-5.39,;16,-7.7,;16,-9.24,;17.34,-10.01,;18.67,-9.24,;20.01,-10.01,;21.34,-9.24,;22.67,-10.01,;22.67,-11.55,;24.01,-12.32,;25.34,-11.55,;25.34,-10.01,;24.01,-9.24,;26.67,-12.32,;26.67,-13.86,;28.01,-14.63,;29.34,-13.86,;30.81,-14.34,;31.28,-15.8,;31.71,-13.09,;33.25,-13.09,;34.02,-14.42,;35.56,-14.42,;36.33,-13.09,;37.87,-13.09,;35.56,-11.76,;34.02,-11.76,;33.25,-10.42,;30.81,-11.84,;31.28,-10.38,;29.34,-12.32,;28.01,-11.55,;18.67,-7.7,;17.34,-6.93,;)|
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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