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Flavokawain A
Price range: 67 CAD through 106 CAD
Products Details
Product Description
– NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
Web ID
– T3S0737
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H18O5
Citations
– 1. Xiao T, Bao J, Tian J, et al.Flavokawain A suppresses the vasculogenic mimicry of HCC by inhibiting CXCL12 mediated EMT.Phytomedicine.2023: 154687.
References
– Kwon D J , Ju S M , Youn G S , et al. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages[J]. Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association, 2013, 58(3):479-486.
CAS Number
– 3420-72-2
Molecular Weight
– C18H18O5
Compound Purity
– 0.9972
SMILES
– O=C(C=CC1=CC=C(OC)C=C1)C=2C(O)=CC(OC)=CC2OC
Pathway
– MAPK|||Apoptosis
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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