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GNE-274
1,195 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.
Web ID
– T39916
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H31NO4
References
– Jane Guan, et al. Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility. Cell. 2019 Aug 8;178(4):949-963.e18.
CAS Number
– 2369048-69-9
Molecular Weight
– C29H31NO4
SMILES
– CCCN1CC(COc2ccc(cc2)[C@@H]2Oc3ccc(O)cc3C(C)=C2c2cccc(O)c2)C1
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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