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Products Details
Product Description
– Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.
Web ID
– T39818
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C30H33N5O7S
References
– Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
CAS Number
– 2292116-14-2
Molecular Weight
– C30H33N5O7S
SMILES
– CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCOCCOCCC(O)=O)ccc32)no1
Pathway
– Others
Product type
– PROTAC
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