TH5427 hydrochloride
Add to CompareAdded to Compare

Download Files:

TH5427 hydrochloride

SKU T39785-10 mg Category Brand:

Request Pricing

Products Details

Product Description

– TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.

Web ID

– T39785

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H21Cl3N8O3

References

– Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.

CAS Number

– 2253744-57-7

Molecular Weight

– C20H21Cl3N8O3

SMILES

– Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
6-Mercaptopurine
6-Mercaptopurine Price range: 50 CAD through 190 CAD
1 g1 mL * 10 mM (in DMSO)25 mg

1000 in stock

Select options
Procainamide hydrochloride
Procainamide hydrochloride Price range: 50 CAD through 317 CAD
1 g1 mL * 10 mM (in DMSO)25 mg

1000 in stock

Select options
Sodium Nitroprusside
Sodium Nitroprusside Price range: 64 CAD through 139 CAD
1 mL * 10 mM (in DMSO)100 mg50 mg

1000 in stock

Read more
(R)-(+)-Atenolol
(R)-(+)-Atenolol
Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });