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Products Details
Product Description
– Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3′ splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
Web ID
– T39071
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H41NO8
References
– Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130.
CAS Number
– 1609105-89-6
Molecular Weight
– C28H41NO8
SMILES
– C[C@H](OC(C)=O)C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](CC=C(/C)C=C[C@@H]2C[C@]3(CO3)C[C@@H](CC(O)=O)O2)O[C@@H]1C
Pathway
– Others
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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