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14,15-dehydro Leukotriene B4

SKU T37260-25 μg Category Brand:

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Products Details

Product Description

– Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.

Web ID

– T37260

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H30O4

CAS Number

– 114616-11-4

Molecular Weight

– C20H30O4

SMILES

– C(=CC=CC=C[C@@H](CC#CCCCCC)O)[C@H](CCCC(O)=O)O

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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