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Cinacalcet
$35 – $180
Products Details
Product Description
– Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.
Web ID
– HY-70037
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H22F3N
Citations
– Acta Physiol. 2023 Jan 6;e13926.|Calcif Tissue Int. 2023 Feb 8.|Cell Biol Toxicol. 2022 May 30.|Gen Comp Endocrinol. 2018 Oct 1;267:1-8.|J Agric Food Chem. 2021 Nov 8.|J Biol Chem. 2016 Oct 28;291(44):23126-23135.|J Food Sci. 2018 Sep;83(9):2394-2401.|J Med Chem. 2015 Apr 9;58(7):2958-66. |Oxid Med Cell Longev. 2017;2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.|iScience. 2023 Mar.|Patent. US20230147129A1.
References
– [1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.
CAS Number
– 226256-56-0
Molecular Weight
– 357.41
Compound Purity
– 99.97
SMILES
– FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– CaSR;Endogenous Metabolite
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
