(E)-SIS3
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(E)-SIS3

SKU T3636-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 2,480 CAD

Products Details

Product Description

– (E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

Web ID

– T3636

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H27N3O3·HCl

Citations

– 1. Xu J, Ma L, Wang D, et al. Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway. BMC Molecular and Cell Biology. 2022, 23(1): 1-17 2. Yao H, Qian J, Bian X, et al.miR-27b-3p reduces muscle fibrosis during chronic skeletal muscle injury by targeting TGF-βR1/Smad pathway.Journal of Orthopaedic Surgery and Research.2024, 19(1): 329. 3. The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease[J]. Cell Death & Disease, 2025, 16(1): 14.

References

– Jinnin M, et al. Mol Pharmacol. 2006, 69(2):597-607.

CAS Number

– 521984-48-5

Molecular Weight

– C28H27N3O3·HCl

Compound Purity

– 0.9883

SMILES

– Cl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc1c(-c2ccccc2)n(C)c2ncccc12

Target

– CDK

Pathway

– Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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