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Cobimetinib
Price range: 54 CAD through 763 CAD
Products Details
Product Description
– Cobimetinib (GDC-0973) is a MEK1 inhibitor (IC50=4.2 nM) with selective and oral activity. Cobimetinib exhibits antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.
Web ID
– T3623
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H21F3IN3O2
Citations
– 1. Meng Y, Lv T, Zhang J, et al.Temporospatial inhibition of Erk signaling is required for lymphatic valve formation.Signal Transduction and Targeted Therapy.2023, 8(1): 342.
2. Yang Y, Suo N, Cui S, et al.Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2024: 1-13.
References
– Hoeflich KP, et al. Cancer Res. 2012, 72(1), 210-219.
CAS Number
– 934660-93-2
Molecular Weight
– C21H21F3IN3O2
Compound Purity
– 0.9998
SMILES
– C(=O)(C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)N3C[C@](O)(C3)[C@@H]4CCCCN4
Target
– PAI-1
Pathway
– Apoptosis|||MAPK
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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