Rebastinib
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Rebastinib

SKU T2640-2 mg Category Brand:

Price range: 64 CAD through 955 CAD

Products Details

Product Description

– DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Rebastinib aimed at the Angiopoietin2-Tie2 pathway.

Web ID

– T2640

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H28FN7O3

Citations

– 1. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866.

References

– Chan WW, et al. Cancer Cell. 2011, 19(4), 556-568.

CAS Number

– 1020172-07-9

Molecular Weight

– C30H28FN7O3

Compound Purity

– 0.9984

SMILES

– CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1

Pathway

– Cytoskeletal Signaling|||Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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