Silmitasertib
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Silmitasertib

SKU T2259-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 1,872 CAD

Products Details

Product Description

– Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).

Web ID

– T2259

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H12ClN3O2

Citations

– 1. Wang C, Tian L, He Q, et al.Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors.Oncogene.2023: 1-14. 2. Werner C, Lindenblatt D, Viht K, et al.Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2α′ Cys336Ser as an Exquisite Crystallographic Tool.Kinases and Phosphatases.2023, 1(4): 306-322. 3. Haga Y, Ray R, Ray R B.Silmitasertib in Combination With Cabozantinib Impairs Liver Cancer Cell Cycle Progression, Induces Apoptosis, and Delays Tumor Growth in a Preclinical Model.Molecular Carcinogenesis.2024

References

– Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98.

CAS Number

– 1009820-21-6

Molecular Weight

– C19H12ClN3O2

Compound Purity

– 0.9961

SMILES

– OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21

Pathway

– Metabolism|||Autophagy|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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