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GNE-490
Price range: 123 CAD through 2,160 CAD
Products Details
Product Description
– GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).
Web ID
– T22339
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H22N6O2S
References
– Daniel P Sutherlin, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97.
CAS Number
– 1033739-92-2
Molecular Weight
– C18H22N6O2S
Compound Purity
– 0.9977
SMILES
– Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
Target
– Others
Pathway
– PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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