Tazemetostat
Add to CompareAdded to Compare

Download Files:

Tazemetostat

SKU T1788-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 645 CAD

Products Details

Product Description

– Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epithelioid sarcoma/follicular lymphoma.

Web ID

– T1788

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C34H44N4O4

Citations

– 1. Song P, Duan J L, Ding J, et al.Cellular senescence primes liver fibrosis regression through Notch‐EZH2.MedComm.2023, 4(5): e346. 2. Zhang Q, Chen X, Cao J, et al.Discovery of a Novel Covalent EZH2 Inhibitor Based on Tazemetostat Scaffold for the Treatment of Ovarian Cancer.Journal of Medicinal Chemistry.2023 3. Yang Y, Xiao L, Xue Y, et al.ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by Zinc Fingers 1–2 and recognition of γ‐globin− 200 gene element by Zinc Fingers 1–4.The FEBS Journal.2023 4. Gu T, Xu C, Meng X, et al.Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder—Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.Journal of Molecular Neuroscience.2023: 1-12. 5. Ghildiyal R, Sawant M, Renganathan A, et al. Loss of Long Noncoding RNA NXTAR in Prostate Cancer Augments Androgen Receptor Expression and Enzalutamide ResistanceTumor Suppressor lncRNA NXTAR Inhibits AR/AR-V7 Expression. Cancer Research. 2022, 82(1): 155-168 6. Ghildiyal R, Sawant M, Renganathan A, et al. Loss of long non-coding RNA NXTAR in prostate cancer augments androgen receptor expression and enzalutamide resistance. Cancer Research. 2021 7. Ghildiyal R, Sawant M, Renganathan A, et al. Loss of Long Noncoding RNA NXTAR in Prostate Cancer Augments Androgen Receptor Expression and Enzalutamide Resistance. Cancer Research. 2022, 82(1): 155-168 8. Luo Y, Fang Y, Kang R, et al. Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. Stroke. 2020: STROKEAHA. 120.029951 9. Zhang L, Qu J, Qi Y, et al. EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation. Nature Communications. 2022, 13(1): 1-16 10. Cao Shangtao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang et al. Chromatin accessibility dynamics during chemical induction of pluripotency. Cell Stem Cell. 2018, 22(4): 529-542. e5

References

– Kawano S, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS One. 2016 Jul 8;11(7):e0158888.

CAS Number

– 1403254-99-8

Molecular Weight

– C34H44N4O4

Compound Purity

– 0.9972

SMILES

– CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1

Target

– Others

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Mephenesin
Mephenesin Price range: 53 CAD through 173 CAD
1 g10 g5 g

1000 in stock

Select options
Procainamide hydrochloride
Procainamide hydrochloride Price range: 50 CAD through 317 CAD
1 g1 mL * 10 mM (in DMSO)25 mg

1000 in stock

Select options
Flubendazole
Flubendazole Price range: 53 CAD through 149 CAD
1 mL * 10 mM (in DMSO)100 mg50 mg

1000 in stock

Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

Select options
7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinoline Price range: 56 CAD through 77 CAD
100 mg200 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });