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CLP257
Price range: 61 CAD through 1,157 CAD
Products Details
Product Description
– CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.
Web ID
– T14984
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H14FN3O2S
References
– Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8.
CAS Number
– 1181081-71-9
Molecular Weight
– C14H14FN3O2S
Compound Purity
– 0.995
SMILES
– Oc1cc(F)ccc1C=C1/SC(=NC1=O)N1CCCCN1
Target
– Beta-Secretase|||Sodium Channel
Pathway
– Membrane transporter/Ion channel
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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