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Doxorubicin
Price range: 62 CAD through 86 CAD
Products Details
Product Description
– Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Web ID
– T1456
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H29NO11
Citations
– 1. Wu T Y, Chen X C, Tang G X, et al.Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c-MYC Transcription Inhibitors.Journal of Medicinal Chemistry.2023
2. Qian S, Han Y, Zhang Y, et al.Discovery of AHCY as an Off-Target of Doxorubicin by Integrative Analysis of Photoaffinity Labeling Chemoproteomics and Untargeted Metabolomics.Analytical Chemistry.2022
3. Zhao J, Xu J, Wu M, et al.LncRNA H19 Regulates Breast Cancer DNA Damage Response and Sensitivity to PARP Inhibitors via Binding to ILF2.International Journal of Molecular Sciences.2023, 24(11): 9157.
4. Len J M, Hussein N, Malla S, et al. A Novel Dialkylamino-Functionalized Chalcone, DML6, Inhibits Cervical Cancer Cell Proliferation, In Vitro, via Induction of Oxidative Stress, Intrinsic Apoptosis and Mitotic Catastrophe. Molecules. 2021, 26(14): 4214.
5. Liang L, Tu Y, Lu J, et al. Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting Wnt/β-catenin signaling pathway. J Cell Sci. 2019 May 16;132(10)
6. Abramczyk O, Stawieraj S, Mlicka A, et al.Effect of combined action of doxorubicin and calcifediol on MCF-7 breast cancer cells.Medical Research Journal.2023
7. YILDIZHAN K, HUYUT Z, ALTINDAĞ F, et al.EFFECT OF SELENIUM AND N-(P-AMYLCINNAMOYL) ANTHRANILIC ACID ON DOXORUBICIN-INDUCED KIDNEY INJURY IN RATS.İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi.11(1): 1181-1191.
8. Li G J, Wang C, Wang W D, et al.Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP.Journal of Asian Natural Products Research.2024: 1-16.
9. Li T, Wan Z, Wang Q, et al.Utilizing Tissues Self‐Assembled in Fiber Optic‐Based “Chinese Guzheng Strings” for Contractility Sensing and Drug Efficacy Evaluation: A Practical Approach.Small.2406144
10. The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease[J]. Cell Death & Disease, 2025, 16(1): 14.
References
– Nitiss JL, et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May;9(5):338-50.
CAS Number
– 23214-92-8
Molecular Weight
– C27H29NO11
Compound Purity
– 0.9931
SMILES
– COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Target
– Others
Pathway
– PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Antibody-drug Conjugate/ADC Related|||DNA Damage/DNA Repair
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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