PF-3450074
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PF-3450074

SKU T16500-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 46 CAD through 565 CAD

Products Details

Product Description

– PF-3450074 (PF-74) acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage and polyadenylation specific factor 6) and NUP153 (nucleoporin 153), and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. PF-3450074 is a specifical inhibitor of HIV-1 capsid protein (CA) and shows a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM).

Web ID

– T16500

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H27N3O2

References

– Xu JP, et al. Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.J Drug Des Res. 2018;5(2). pii: 1070. Epub 2018 Aug 13.

CAS Number

– 1352879-65-2

Molecular Weight

– C27H27N3O2

Compound Purity

– 0.9992

SMILES

– CN(C(=O)[C@H](Cc1ccccc1)NC(=O)Cc1c(C)[nH]c2ccccc12)c1ccccc1

Target

– ADC Linker

Pathway

– Proteases/Proteasome|||Microbiology/Virology

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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