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GNE-781
Price range: 147 USD through 2,220 USD
Products Details
Product Description
– GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
Web ID
– T15405
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H33F2N7O2
Citations
– 1. Wang L, Wu J, Sramek M, et al.Heterogeneous enhancer states orchestrate β cell responses to metabolic stress.Nature Communications.2024, 15(1): 9361.
References
– Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.
CAS Number
– 1936422-33-1
Molecular Weight
– C27H33F2N7O2
Compound Purity
– 0.9992
SMILES
– CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
Target
– Others
Pathway
– Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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