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MR-L2
Price range: 237 CAD through 5,264 CAD
Products Details
Product Description
– MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
Web ID
– T12103
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H16Cl3FN4O
Citations
– 1. Sharp B M, Jiang Q, Kim P, et al.Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 modulates the motivation to chronically self-administer nicotine.bioRxiv.2023: 2023.03. 07.531588.
2. Sharp B M, Jiang Q, Kim P, et al.Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific Reports.2024, 14(1): 2562.
References
– Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
CAS Number
– 2374703-19-0
Molecular Weight
– C19H16Cl3FN4O
Compound Purity
– 0.9809
SMILES
– CCc1nc(nn1CC(=O)NCc1cc(Cl)cc(Cl)c1)-c1ccc(Cl)c(F)c1
Target
– mTOR|||PI3K
Pathway
– Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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