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Carboplatin
Price range: 58 CAD through 266 CAD
Products Details
Product Description
– Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.
Web ID
– T1058
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C6H12N2O4Pt
Citations
– 1. Liu L, Liu S, Deng P, et al. Targeting the IRAK1-S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma. Cancer Research. 2021 Mar 1;81(5):1413-1425. doi: 10.1158/0008-5472.CAN-20-2125. Epub 2021 Jan 5.
2. Liu L, Liu S, Deng P, et al. Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma. Cancer Research. 2021, 81(5): 1413-1425.
3. Bi G, Liang J, Zhao M, et al. MiR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma by targeting CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways. Molecular Therapy-Nucleic Acids. 2022
4. Zhu H, Rao Z, Yuan S, et al. One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin. European Journal of Pharmacology. 2021: 174366.
5. Guo A, Lin J, Zhong P, et al.Phellopterin attenuates ovarian cancer proliferation and chemoresistance by inhibiting the PU. 1/CLEC5A/PI3K-AKT feedback loop.Toxicology and Applied Pharmacology.2023: 116691.
6. Lin Y, Chen X, Lin L, et al.Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3β/β-catenin signaling.Cellular & Molecular Biology Letters.2024, 29(1): 63.
7. Zhao X, Zhao Z, Li B, et al.ACSL4-mediated lipid rafts prevent membrane rupture and inhibit immunogenic cell death in melanoma.Cell Death & Disease.2024, 15(9): 695.
8. Peng T, Ma X, Hua W, et al.Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy.Cell Stem Cell.2025
References
– Wang S, et al. Analysis of the cytotoxic activity of carboplatin and gemcitabine combination. Anticancer Res. 2010 Nov;30(11):4573-8.
CAS Number
– 41575-94-4
Molecular Weight
– C6H12N2O4Pt
Compound Purity
– 0.9971
SMILES
– [NH2-].[NH2-].[Pt+4].[O-]C(=O)C1(CCC1)C([O-])=O
Target
– Others
Pathway
– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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