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ZXH-1-161
$250 – $1,800
Products Details
Product Description
– ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].
Web ID
– HY-147158
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H24N6O3
References
– [1]Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.
CAS Number
– 2407654-51-5
Molecular Weight
– 468.51
Compound Purity
– 98.92
SMILES
– O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Ligands for E3 Ligase;Molecular Glues
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
