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ZSET1446
SKU
HY-11013-1 mg
Category Reference compound
Tags Calcium Channel;nAChR, Membrane Transporter/Ion Channel;Neuronal Signaling, Neurological Disease; Cancer
$100 – $1,050
Products Details
Product Description
– ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
Web ID
– HY-11013
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C15H12N2O
References
– [1]Takeda K, et al. Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus. J Pharmacol Exp Ther. 2016 Feb;356(2):445-55|[2]Yamaguchi Y, et al. Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. J Pharmacol Sci. 2013;123(4):347-55. Epub 2013 Nov 29.|[3]Yamaguchi Y, et al. Effects of ZSET1446/ST101 on cognitive deficits and amyloid β deposition in the senescence accelerated prone mouse brain. J Pharmacol Sci. 2012;119(2):160-6.
CAS Number
– 887603-94-3
Molecular Weight
– 236.27
Compound Purity
– 98.07
SMILES
– O=C1N=C2C=CC=CN2C13CC4=C(C=CC=C4)C3
Clinical Information
– Phase 2
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Calcium Channel;nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.