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Zoledronic Acid
$96 – $156
Products Details
Product Description
– Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1].
Web ID
– HY-13777
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C5H10N2O7P2
Citations
– ACS Nano. 2023 Jul 10.|Int Immunopharmacol. September 2022, 109030.|Med Oncol. 2023 Apr 10;40(5):141.|Oxid Med Cell Longev. 2021 Mar 31.|Dis Markers. 2021 Oct 15;2021:5838582.|Gut Microbes. 2023 Dec;15(2):2249143.
References
– [1]Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059.|[2]Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20(6): 1467.|[3]Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44(2):582-592.|[4]XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13(1): 613-622.|[5]Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15(18):5829-39.|[6]Shea GKH, et al. Oral Zoledronic acid bisphosphonate for the treatment of chronic low back pain with associated Modic changes: A pilot randomized controlled trial. J Orthop Res. 2022 Feb 23.
CAS Number
– 118072-93-8
Molecular Weight
– 272.09
Compound Purity
– 99.00
SMILES
– OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease
Solubility
– H2O : 4.81 mg/mL (ultrasonic;warming;adjust pH to 6 with NaOH;heat to 60°C)
Target
– Apoptosis;Autophagy;Bacterial
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
