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Products Details
Product Description
– ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].
Web ID
– HY-147772
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H15N3O2
References
– [1]Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401.
CAS Number
– 2541604-52-6
Molecular Weight
– 293.32
SMILES
– O=C1C=CCCN1C(/C=C/C2=CC=CC=C2C3=CNC=N3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Indoleamine 2,3-Dioxygenase (IDO);Reactive Oxygen Species
Isoform
– IDO1
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
