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Products Details
Product Description
– Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].
Web ID
– HY-75385A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H29BrN4O3.1/2H2O4S
References
– [1]Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91.|[2]Davenport RJ, et al. Alpha4-integrin antagonism–an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76.
CAS Number
– 1214261-78-5
Molecular Weight
– 647.54
SMILES
– O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O.O=S(O)(O)=O
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Integrin
Pathway
– Cytoskeleton
Product type
– Reference compound
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