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Zapnometinib
$60 – $395
Products Details
Product Description
– Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities[1][2][3].
Web ID
– HY-139558
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C13H7ClF2INO2
References
– [1]Laure M, et, al. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Jun;178:104806.|[2]Hamza H, et, al. Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002. Front Microbiol. 2021 Feb 12;12:611958.|[3]Bruchhagen C, et, al. Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound. Sci Rep. 2018 Jun 14;8(1):9114.
CAS Number
– 303175-44-2
Molecular Weight
– 409.55
Compound Purity
– 99.63
SMILES
– O=C(O)C1=CC=C(F)C(F)=C1NC2=CC=C(I)C=C2Cl
Clinical Information
– Phase 2
Research Area
– Cancer; Infection
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– Bacterial;Influenza Virus;MEK
Isoform
– MEK
Pathway
– Anti-infection;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
