Zanubrutinib

SKU HY-101474A-10 mg Category Tags , ,

$180$1,300

Products Details

Product Description

– Zanubrutinib (BGB-3111) is a selective and orally active Bruton tyrosine kinase (Btk) inhibitor (IC50: 0.3 nM)[1][2].

Web ID

– HY-101474A

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C27H29N5O3

References

– [1]Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton’s tyrosine kinase (BTK) inhibitor. Cancer Res 2015;75(15 Suppl):Abstract nr 2597.|[2]Guo Y, et al. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. J Med Chem. 2019 Sep 12;62(17):7923-7940.

CAS Number

– 1691249-45-2

Molecular Weight

– 471.55

Compound Purity

– 99.45

SMILES

– NC(C1=C2N(N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H](C5CCN(C(C=C)=O)CC5)CCN2)=O

Clinical Information

– Launched

Research Area

– Cancer

Solubility

– DMSO : 200 mg/mL (ultrasonic)|Ethanol : < 1 mg/mL

Target

– Btk

Pathway

– Protein Tyrosine Kinase/RTK

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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