Z-VAD(OMe)-FMK
Add to CompareAdded to Compare

Download Files:

Z-VAD(OMe)-FMK

SKU T6013-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 83 CAD through 1,571 CAD

Products Details

Product Description

– Z-VAD(OMe)-FMK is a pan-caspase inhibitor with irreversible properties; Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C terminal hydrolase L1 (UCHL1), which is irreversibly modified by targeting the UCHL1 active site.

Web ID

– T6013

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H30FN3O7

Citations

– 1. Bi G, Liang J, Shan G, et al.Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells.Cancer Research.2023: CAN-22-3977. 2. Li Y, Yang W, Zheng Y, et al.Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.Journal of Experimental & Clinical Cancer Research.2023, 42(1): 1-19. 3. Quan D, Hou R, Shao H, et al.Structure-Based Design of Novel Alkynyl Thio-Benzoxazepinone Receptor-Interacting Protein Kinase-1 Inhibitors: Extending the Chemical Space from the Allosteric to ATP Binding Pockets.Journal of Medicinal Chemistry.2023 4. Zhang X, Han Q, Hou R, et al.Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway.Journal of Medicinal Chemistry.2023 5. Yang W, Sun X, Liu S, et al.TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia.Biomedicine & Pharmacotherapy.2023, 163: 114759. 6. Cui N, Li S, Zhang Y, et al.Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors.European Journal of Medicinal Chemistry.2023: 115190. 7. Urade R, Chang W T, Ko C C, et al.A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.Life Sciences.2023: 121835. 8. Xu Y, Liang C, Zhang W, et al.Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors.Bioorganic Chemistry.2022: 106339. 9. Tang J, Wu Y, Zhao W, et al.Scaffold hopping derived novel benzoxazepinone RIPK1 inhibitors as anti-necroptosis agents.Bioorganic & Medicinal Chemistry.2023: 117385. 10. Yang D L, Zhang Y, He L, et al. Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux. Biological Research. 2021, 54(1): 1-14.

References

– Shimizu T, et al. Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases. Leukemia. 1997 Aug;11(8):1238-44.

CAS Number

– 187389-52-2

Molecular Weight

– C22H30FN3O7

Compound Purity

– 0.9944

SMILES

– COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF

Pathway

– Apoptosis|||Proteases/Proteasome

Product type

– Peptide

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Read more
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Select options
Bax inhibitor peptide V5 acetate
Bax inhibitor peptide V5 acetate Price range: 70 CAD through 1,294 CAD
2 mg1 mg1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Aspartyl-alanyl-diketopiperazine acetate
Aspartyl-alanyl-diketopiperazine acetate Price range: 150 CAD through 1,952 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA Price range: 315 CAD through 1,275 CAD
1 mg10 mg5 mg

1000 in stock

Select options
Aspartame
Aspartame Price range: 72 CAD through 99 CAD
1 g1 mL * 10 mM (in DMSO)500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });