YX-2-107
Add to CompareAdded to Compare

Download Files:

YX-2-107

SKU T74710-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 362 CAD through 5,376 CAD

Products Details

Product Description

– YX-2-107 is a selective and potent CDK6-degrading PROTAC with an IC50 value of 4.4 nM.YX-2-107 inhibits RB phosphorylation and FOXM1 expression in vitro, and inhibits the development of Ph+ ALL in rats.YX-2-107 can be used for the prophylaxis and treatment of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). YX-2-107 can be used for the prevention and treatment of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

Web ID

– T74710

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C45H51N11O9

References

– De Dominici M, et al. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs. Blood. 2020 Apr 30;135(18):1560-1573.

CAS Number

– 2417408-46-7

Molecular Weight

– C45H51N11O9

Compound Purity

– 0.9809

SMILES

– O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCC(=O)NCCCCNCC(=O)N4CCN(C5=CN=C(C=C5)NC=6N=CC7=C(N6)N(C(=O)C(C(=O)C)=C7C)C8CCCC8)CC4)C3C2=O)CC1

Pathway

– Cell Cycle/Checkpoint|||PROTAC

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
GNE-987
GNE-987 Price range: 790 CAD through 2,848 CAD
1 mg10 mg5 mg

1000 in stock

Select options
Dxd
Dxd Price range: 62 CAD through 373 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
CDK9-IN-11
CDK9-IN-11 Price range: 2,432 CAD through 4,000 CAD
100 mg25 mg50 mg

1000 in stock

Select options
CDK ligand for PROTAC hydrochloride
CDK ligand for PROTAC hydrochloride Price range: 498 CAD through 3,170 CAD
1 mL * 10 mM (in DMSO)10 mg5 mg

1000 in stock

Select options
Thalidomide
Thalidomide Price range: 80 CAD through 155 CAD
1 mL * 10 mM (in DMSO)200 mg500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });