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YNT-185 (dihydrochloride)
$180 – $1,450
Products Details
Product Description
– YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].
Web ID
– HY-136181
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C33H39Cl2N5O5S
References
– [1]Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937.|[2]Irukayama-Tomobe Y, et al. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017;114(22):5731-5736.
CAS Number
– 1804978-82-2
Molecular Weight
– 688.66
Compound Purity
– 99.78
SMILES
– O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Orexin Receptor (OX Receptor)
Isoform
– OX1 Receptor;OX2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
