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YM-201636
SKU
HY-13228-10 mg
Category Reference compound
Tags Anti-infection;Autophagy;PI3K/Akt/mTOR, Autophagy;Influenza Virus;PI3K;PIKfyve, Cancer; Infection
$73 – $1,452
Products Details
Product Description
– YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.
Web ID
– HY-13228
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H21N7O3
References
– [1]Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9(2), 164-170.|[2]Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.|[3]Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46.|[4]Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7(3):e28659.|[5]Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
CAS Number
– 371942-69-7
Molecular Weight
– 467.48
Compound Purity
– 98.06
SMILES
– O=C(NC1=CC=CC(C2=NC(N3CCOCC3)=C4OC5=NC=CC=C5C4=N2)=C1)C6=CC=C(N=C6)N
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– DMSO : ≥ 47 mg/mL
Target
– Autophagy;Influenza Virus;PI3K;PIKfyve
Isoform
– PI3Kα
Pathway
– Anti-infection;Autophagy;PI3K/Akt/mTOR
Product type
– Reference compound
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