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YJ9069

SKU T201264-10 mg Category Brand:

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Products Details

Product Description

– YJ9069 is a selective CDK12/CDK13P ROTAC degrader with an IC50 of 22.22 nM in VCaP cells. Rapid degradation of CDK12/13 by this compound triggers transcription elongation defects dependent on gene length, leading to DNA damage and cell cycle arrest. YJ9069 effectively inhibits the proliferation of prostate cancer cell subpopulations and significantly suppresses prostate tumor growth in vivo.

Web ID

– T201264

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C46H46N10O7

Molecular Weight

– C46H46N10O7

SMILES

– FC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2

Target

– Others

Pathway

– PROTAC|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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