YF135
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YF135

SKU T74336-5 mg Category Brand:

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Products Details

Product Description

– YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhibitor 48 (compound 6d) as the ligand, YF135 utilizes the MRTX849 linkage VHL ligand scaffold.

Web ID

– T74336

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C63H75ClN12O7S

CAS Number

– 2913177-53-2

Molecular Weight

– C63H75ClN12O7S

SMILES

– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=CC2CC2)C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1

Pathway

– Others

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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