YB-3–17
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YB-3–17

SKU T204111-10 mg Category Brand:

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Products Details

Product Description

– YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

Web ID

– T204111

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C38H39N11O6

CAS Number

– 2940242-88-4

Molecular Weight

– C38H39N11O6

SMILES

– O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NCC4CCC(C(=O)N5CCC(N6N=C(C=7C=CC=8OC(=NC8C7)N)C=9C(=NC=NC96)N)CC5)CC4)CC1

Pathway

– PROTAC|||PI3K/Akt/mTOR signaling

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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