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Products Details
Product Description
– WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].
Web ID
– HY-155992
Shipping
– Room temperature
Molecular Formula
– C21H29N5O3
References
– [1]Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519.
CAS Number
– 2849471-75-4
Molecular Weight
– 399.49
SMILES
– O=C(CN1CCC(CC1)C2=C(C3=CC(C)=NO3)C=NC(CC)=N2)N4CCOCC4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Sigma Receptor
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
