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Products Details
Product Description
– WEHI-539 is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM.
Web ID
– HY-15607
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H29N5O3S2
Citations
– Am J Cancer Res. 2019 Dec 1;9(12):2580-2598.|Breast Cancer Res Treat. 2019 Feb;173(3):585-596.|Cancer Biology. 2020 May.|Cell Death Differ. 2014 Jul;21(7):1170-7. |Cell Death Differ. 2017 Jan;24(1):111-119. |Cell Death Dis. 2017 Dec 13;8(12):3216.|Cell Death Dis. 2023 Oct 28;14(10):705.|Cell. 2014 Dec 18;159(7):1549-62.|Clin Cancer Res. 2019 Dec 1;25(23):7139-7150. |J Ovarian Res. 2016 Apr 14;9(1):25. |Nat Commun. 2016 Mar 9;7:10916.|Nature. 2017 Nov 9;551(7679):247-250. |Oncol Rep. 2019 Dec;42(6):2416-2425.|Pharmacol Res. 2022 Dec 21;187:106628.|bioRxiv. 2023 Aug 5.|Blood. 2014 Dec 4;124(24):3587-96. |Cell Death Dis. 2018 Jan 19;9(2):42.|Cell Rep. 2023 Mar 30;42(4):112324.|Int J Cancer. 2018 Feb 1;142(3):584-596.|Malays Appl Biol. (2020) 49(1): 193-197.|Methods Mol Biol. 2018;1711:351-398.|Nat Biotechnol. 2018 Feb;36(2):179-189.|Nat Chem Biol. 2022 Jun;18(6):615-624.|Oncotarget. 2018 May 25;9(40):26046-26063.|The Department of Medical Sciences, Harvard University. 2019 Dec.
References
– [1]Lessene G, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol. 2013 Jun;9(6):390-7.|[2]Abed MN, et al. Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. J Ovarian Res. 2016 Apr 14;9:25.
CAS Number
– 1431866-33-9
Molecular Weight
– 583.72
SMILES
– OC(C1=C(CCCOC2=CC=C(CN)C=C2)SC(C3=CC4=C(CCC/C4=NNC5=NC(C=CC=C6)=C6S5)C=C3)=N1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family
Isoform
– Bcl-xL
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
