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W146 (TFA)
$150 – $5,000
Products Details
Product Description
– W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
Web ID
– HY-101395A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C18H28F3N2O6P
References
– [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.|[2]Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1(4): 197–203.|[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.
CAS Number
– 909725-62-8
Molecular Weight
– 456.39
Compound Purity
– 98.13
SMILES
– O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 22.73 mg/mL (ultrasonic;warming;adjust pH to 3 with 1M HCl;heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;LPL Receptor
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
