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W146 (TFA)
SKU
HY-101395A-1 mg
Category Reference compound
Tags Apoptosis;GPCR/G Protein, Apoptosis;LPL Receptor, Cancer; Metabolic Disease
$150 – $5,000
Products Details
Product Description
– W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
Web ID
– HY-101395A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C18H28F3N2O6P
References
– [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.|[2]Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1(4): 197–203.|[3]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.
CAS Number
– 909725-62-8
Molecular Weight
– 456.39
Compound Purity
– 98.13
SMILES
– O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 22.73 mg/mL (ultrasonic;warming;adjust pH to 3 with 1M HCl;heat to 60°C)|Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;LPL Receptor
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
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