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VU0463271
SKU
HY-110110-10 mg
Category Reference compound
Tags Membrane Transporter/Ion Channel, Neurological Disease, Potassium Channel
$90 – $850
Products Details
Product Description
– VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM.
Web ID
– HY-110110
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H18N4OS2
References
– [1]Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.|[2]Rui Chen, et al. Functional Coupling of K +-Cl – Cotransporter (KCC) to GABA-Gated Cl – Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10(6):2765-2776.
CAS Number
– 1391737-01-1
Molecular Weight
– 382.50
Compound Purity
– 98.49
SMILES
– O=C(N(C1CC1)C2=NC(C)=CS2)CSC3=NN=C(C4=CC=CC=C4)C=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.