VU0463271

$90$850

Products Details

Product Description

– VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM.

Web ID

– HY-110110

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C19H18N4OS2

References

– [1]Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.|[2]Rui Chen, et al. Functional Coupling of K +-Cl – Cotransporter (KCC) to GABA-Gated Cl – Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10(6):2765-2776.

CAS Number

– 1391737-01-1

Molecular Weight

– 382.50

Compound Purity

– 98.49

SMILES

– O=C(N(C1CC1)C2=NC(C)=CS2)CSC3=NN=C(C4=CC=CC=C4)C=C3

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– DMSO : 25 mg/mL (ultrasonic)

Target

– Potassium Channel

Pathway

– Membrane Transporter/Ion Channel

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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