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VU0366248
Price range: 2,432 CAD through 4,000 CAD
Products Details
Product Description
– VU0366248, a negative allosteric modulator of mGlu5, [5-(1,3-Diphenyl-1H-pyrazol-4-yl)-8-ethoxy-3-(4-isopropyl-phenyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine], serves to inhibit the metabotropic glutamate receptor 5 (mGlu5), potentially impacting conditions associated with mGlu5 activity.
Web ID
– T26327
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H7ClF2N2O
References
– Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn ACS Chem Neurosci. 2014 Apr 16; 5(4): 282–295. Published online 2014 Feb 16. doi: 10.1021/cn400225x PMCID: PMC3990945
CAS Number
– 1243310-20-4
Molecular Weight
– C14H7ClF2N2O
SMILES
– C(NC1=C(F)C(Cl)=CC=C1)(=O)C2=CC(C#N)=CC(F)=C2
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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