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VU 0365114
SKU
HY-107651-10 mg
Category Reference compound
Tags GPCR/G Protein;Neuronal Signaling, mAChR, Metabolic Disease
$110 – $759
Products Details
Product Description
– VU 0365114 is a selective mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM, and >30 μM for M1, M2, M3 and M4 receptors. VU 0365114 increases insulin secretion stimulated by ACh in human β-cells[1][2][3].
Web ID
– HY-107651
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C22H14F3NO3
References
– [1]Bridges TM, et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.|[2]Molina J, et al. Control of insulin secretion by cholinergic signaling in the human pancreatic islet. Diabetes. 2014 Aug;63(8):2714-26. |[3]Bridges TM, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62.
CAS Number
– 1208222-39-2
Molecular Weight
– 397.35
Compound Purity
– 99.51
SMILES
– O=C1N(C2=CC=C(OC(F)(F)F)C=C2C1=O)CC3=CC=C(C4=CC=CC=C4)C=C3
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : ≥ 77.5 mg/mL
Target
– mAChR
Isoform
– mAChR5
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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